Brf1 (TFIIB-related factor 1) is a transcription factor, which specifically modulates the transcription of RNA polymerase III-dependent genes (RNA Pol III genes), such as tRNAs and 5S rRNA. The products of tRNAs and 5S rRNA transcription will be changed with the alteration of Brf1 expression. Whereas deregulation of Brf1 and RNA Pol III genes are tightly associated with cell proliferation and transformation, and tumorigenesis. In recent years, emerging studies indicate that Brf1 expression is increased in patients with cancers. In this review, we summarize the progress of the abnormal expression of Brf1 in different human cancers to explore an underlying mechanism and its clinical implication, as well as to prompt its application prospect. With the depth of the Brf1 study and the progress of biotechnology, the status of Brf1 expression may be used as a universal indicator of the early detection and prognosis observation of human cancers.
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Assistant Professor, UCLAS Uttaranchal University, Dehradun, India
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To the editorial team at HSPI and the Journal of Clinical Nephrology:
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Aksenov V.V
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University of Agriculture, Pakistan
Muhammad Sarwar Khan
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University of Jacqmar, Inc., USA
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College of Fisheries, CAU(I), Tripura, India
Ajit Kumar Roy
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Assaf Harofeh Medical Center, Israel
Leonid Feldman
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University of Tubingen, Germany
Yvonne Mast
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Eastern Mediterranean University, Cyprus
Zehra Guchan TOPCU
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USA
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Be well all the year long.
Russia
Victor V Apollonov
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University of Port Harcourt Teaching Hospital, Nigeria
Dr. Elizabeth A Awoyesuku
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NC A&T State University, USA
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Ayokunle Dada
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Ido-Ekiti/Afe Babalola University, Nigeria
Dr. Shuaib Kayode Aremu
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Ekiti State University, Nigeria
Adebukola Ajite
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Wollo University, Ethiopia
Atsedemariam Andualem
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With the best wishes of success, creativity and joy in life, prosperity in the medical field.
Ivano- Frankivsk National Medical University, Ukraine
Nataliya Kitsera
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Thank you very much
Diaverum: PADC, Jeddah, Saudi Arabia
Nasrulla Abutaleb
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Department of Biotechnology, Uttaranchal college of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India
Archna Dhasmana
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BS, PharmD., MBA, CPHIMS, FHIMSS, Adjunct Professor, Global Healthcare Management, MCPHS University, Chief Strategy Offi cer, MedicaSoft, Senior Advisor, National Health IT (NHIT) Collaborative for Underserved, New York HIMSS, National Liaison, Health 2.0 Boston, Past Chair, Chair Innovation, USA
Helen Figge
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Ph.D, Boston University Department of Communication Sciences and Disorders and Knowledge Research Institute, Inc., 2131 Reflection Bay Drive, Arlington, Texas 76013, USA
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Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong
Long Ching
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Palestine College of Nursing, Khan Younis, Gaza Strip, Palestine
Ayman M Abu Mustafa
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Department of Agricultural Economics, Agribusiness and Extension, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
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