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Abstract

Research Article

Nanoencapsulated Extracts from Leaves of Bauhinia forficata Link: In vitro Antioxidant, Toxicogenetic, and Hypoglycemic Activity Effects in Streptozotocin-induced Diabetic Mice

Bárbara Verônica Cardoso de Souza, Alessandra Braga Ribeiro*, Rita de Cássia Meneses Oliveira, Julianne Viana Freire Portela, Ana Amélia de Carvalho Melo Cavalcante, Esmeralda Maria Lustosa Barros, Luís Felipe Lima Matos, Tarsia Giabardo Alves and Maria

Published: 05 September, 2024 | Volume 8 - Issue 1 | Pages: 100-115

In this study, we evaluated the assessed the hypoglycemiant, toxicogenetic and genotoxic effects of nanoencapsulate extracts of Bauhinia forficata Link. Phytochemical evaluations of extracts were carried out, as well as the evaluation using HPLC-MS and of antioxidant capacity in vitro. DM2 was induced in mice with streptozotocin and extracts were given orally for 28 days. That dried extract from infusion (ESIN) had a higher rate of bioactive compounds compared to the dried extract from decoction (ESDC), and higher antioxidant capacity. Glucose levels decreased from 77.26% to 57.79% and 45.15% after supplementation with ESIN (200 and 600 mg/kg/day) and ESDC (600 mg/kg/day), respectively, when compared to the diabetic group treated with metformin (600 mg/kg/day) (21.53%), with an improvement in the glycemic response e recovery of pancreatic β cells. Thus, our study has shown that these extracts exhibit hypoglycemiant activity, with a beneficial effect superior to metformin, as a result they could be considered as potential therapeutic agents for application in pharmaceutical formulations in the treatment of DM2.

Read Full Article HTML DOI: 10.29328/journal.apps.1001063 Cite this Article Read Full Article PDF

Keywords:

Bauhinia forficata Link; Bioactive compounds; Antioxidant capacity; Antidiabetic activity

References

  1. Chatterjee S, Khunti K, Davies MJ. Diabetes type 2. Lancet. 2017;389(10085):2239-2251. Available from: https://doi.org/10.1016/s0140-6736(17)30058-2.
  2. Li C, Bishop TRP, Imamura F, Sharp SJ, Pearce M, Brage S, et al. Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries. Lancet Diabetes Endocrinol. 2024;12(9):619-630. Available from: https://doi.org/10.1016/s2213-8587(24)00179-7.
  3. Ajuwon OR, Ayeleso AO, Adefolaju GA. The Potential of South African Herbal Tisanes, Rooibos and Honeybush in the Management of Type 2 Diabetes Mellitus. Molecules. 2018;23(12):3207. Available from: https://doi.org/10.3390/molecules23123207.
  4. Kangralkar VA, Patil SD, Bandivadekar RM. Oxidative stress and diabetes: a review. Int J Pharm Appl. 2010;1(1):38-45. Available from: http://bipublication.com/files/phv1I120106.pdf.
  5. Moussa SA. Oxidative stress in diabetes mellitus. Rom J Biophys. 2008;18(3):225-236. Available from: https://www.rjb.ro/articles/214/samou.pdf.
  6. Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J. 2016;24(5):547-553. Available from: https://doi.org/10.1016/j.jsps.2015.03.013.
  7. Hanhineva K, Törrönen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykkänen H, et al. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci. 2010;11(4):1365-402. Available from: https://doi.org/10.3390/ijms11041365.
  8. Walton EL. Oxidative stress and diabetes: Glucose response in the cROSsfire. Biomed J. 2017 ;40(5):241-244. Available from: https://doi.org/10.1016/j.bj.2017.10.001.
  9. Zhu D, Zhang X, Niu Y, Diao Z, Ren B, Li X, et al. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food Chem Toxicol. 2017;107(Pt A):138-149. Available from: https://doi.org/10.1016/j.fct.2017.06.041.
  10. Trojan-Rodrigues M, Alves TL, Soares GL, Ritter MR. Plants used as antidiabetics in popular medicine in Rio Grande do Sul, southern Brazil. J Ethnopharmacol. 2012;139(1):155-63. Available from: https://doi.org/10.1016/j.jep.2011.10.034
  11. Alkhalidy H, Moore W, Wang Y, Luo J, McMillan RP, Zhen W, et al. The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production. Molecules. 2018;23(9):2338. Available from: https://doi.org/10.3390/molecules23092338
  12. Ecker A, Gonzaga TKSDN, Seeger RL, Santos MMD, Loreto JS, Boligon AA, et al. High-sucrose diet induces diabetic-like phenotypes and oxidative stress in Drosophila melanogaster: Protective role of Syzygium cumini and Bauhinia forficata. Biomed Pharmacother. 2017;89:605-616. Available from: https://doi.org/10.1016/j.biopha.2017.02.076
  13. Da Cunha AM, Menon S, Menon R, Couto AG, Bürger C, Biavatti MW. Hypoglycemic activity of dried extracts of Bauhinia forficata Link. Phytomedicine. 2010;17(1):37-41. Available from: https://doi.org/10.1016/j.phymed.2009.06.007.
  14. Jorge AP, Horst H, de Sousa E, Pizzolatti MG, Silva FR. Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle. Chem Biol Interact. 2004;149(2-3):89-96. Available from: https://doi.org/10.1016/j.cbi.2004.07.001
  15. Khalil NM, Pepato MT, Brunetti IL. Free radical scavenging profile and myeloperoxidase inhibition of extracts from antidiabetic plants: Bauhinia forficata and Cissus sicyoides. Biol Res. 2008;41(2):165-171. Available from: http://dx.doi.org/10.4067/S0716-97602008000200006.
  16. Pizzolatti MG, Cunha Jr A, Szpoganicz B, Sousa ED, Braz-Filho R, Schripsema J. Flavonoids glycosides from leaves and flowers of Bauhinia forficata (Leguminosae). Quim Nova. 2003;26(4):466-469. Available from: https://doi.org/10.1590/S0100-40422003000400003.
  17. Salatino A, Blatt CT, Santos DYD, Vaz AM. Foliar flavonoids of nine species of Bauhinia. Braz J Bot. 1999;22(1):17-20. Available from: https://doi.org/10.1590/S0100-84041999000100003.
  18. Salgueiro AC, Folmer V, da Silva MP, Mendez AS, Zemolin AP, Posser T, et al. Effects of Bauhinia forficata Tea on Oxidative Stress and Liver Damage in Diabetic Mice. Oxid Med Cell Longev. 2016;2016:8902954. Available from: https://doi.org/10.1155/2016/8902954.
  19. da Silva KL, Biavatti MW, Leite SN, Yunes RA, Delle Monache F, Cechinel Filho V. Phytochemical and pharmacognositc investigation of Bauhinia forficata Link (Leguminosae). Z Naturforsch C J Biosci. 2000;55(5-6):478-80. Available from: https://doi.org/10.1515/znc-2000-5-627.
  20. de Sousa E, Zanatta L, Seifriz I, Creczynski-Pasa TB, Pizzolatti MG, Szpoganicz B, Silva FR. Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves. J Nat Prod. 2004;67(5):829-32. Available from: https://doi.org/10.1021/np030513u.
  21. Tzeng YM, Chen K, Rao YK, Lee MJ. Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes. Eur J Pharmacol. 2009;607(1-3):27-34. Available from: https://doi.org/10.1016/j.ejphar.2009.01.023.
  22. Vinayagam R, Xu B. Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nutr Metab (Lond). 2015;12(1):60. Available from: https://doi.org/10.1186/s12986-015-0057-7.
  23. Alonso-Castro AJ, Ortiz-Sánchez E, García-Regalado A, Ruiz G, Núñez-Martínez JM, González-Sánchez I, et al. Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects. J Ethnopharmacol. 2013;145(2):476-89. Available from: https://doi.org/10.1016/j.jep.2012.11.016.
  24. Cechinel-Zanchett CC, Boeing T, Somensi LB, et al. Flavonoid-rich fraction of Bauhinia forficata Link leaves prevents the intestinal toxic effects of irinotecan chemotherapy in IEC-6 cells and in mice. Phytother Res. 2019;33:90-106. Available from: https://doi.org/10.1002/ptr.6202.
  25. Miceli N, Buongiorno LP, Celi MG, Cacciola F, Dugo P, Donato P, et al. Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link. (Fabaceae) leaves extract. Nat Prod Res. 2016;30(11):1229-39. Available from: https://doi.org/10.1080/14786419.2015.1050671.
  26. De Pontes MAN, De Lima DS, De Oliveira HMBF, De Oliveira Filho AA. Bauhinia forficata L. and its hypoglycemic action. Arch Health Investig. 2017;6(11). Available from: https://doi.org/10.21270/archi.v6i11.2244.
  27. de Souza BVC, Moreira Araújo RSDR, Silva OA, Faustino LC, Gonçalves MFB, Dos Santos ML, et al. Bauhinia forficata in the treatment of diabetes mellitus: a patent review. Expert Opin Ther Pat. 2018;28(2):129-138. Available from: https://doi.org/10.1080/13543776.2018.1409208.
  28. Arpagaus C, Collenberg A, Rütti D, Assadpour E, Jafari SM. Nano spray drying for encapsulation of pharmaceuticals. Int J Pharm. 2018;546(1-2):194-214. Available from: https://doi.org/10.1016/j.ijpharm.2018.05.037.
  29. Cechinel-Zanchett CC, De Andrade SF, Cechinel-Filho V. Ethnopharmacological, phytochemical, pharmacological and toxicological aspects of Bauhinia forficata: A mini-review covering the last five years. Nat Prod Commun. 2018;13(7):911-916. Available from: https://doi.org/10.1177/1934578X1801300732.
  30. Funes-Rivera S, Kennedy ML, Galeano AK, Torres PMF, Campuzano-Bublitz MA. Methanol extract of Bauhinia forficata leaves reduced serum creatinine level and prevented the elevation of hepatic enzymes in mice exposed to gentamicin and acetaminophen: an exploratory study. Biomed Biopharm Res. 2023;20(1):64-82. Available from: http://dx.doi.org/10.19277/bbr.20.1.311.
  31. Chan K, Shaw D, Simmonds MS, Leon CJ, Xu Q, Lu A, et al. Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica. J Ethnopharmacol. 2012;140(3):469-75. Available from: doi: https://doi.org/10.1016/j.jep.2012.01.038.
  32. Menezes FDS, Minto ABM, Ruela HS, Kuster RM, Sheridan H, Frankish N, et al. Hypoglycemic activity of two Brazilian Bauhinia species: Bauhinia forficata L. and Bauhinia monandra Kurz. Rev Bras Farmacogn. 2007;17(1):8-13. Available from: https://doi.org/10.1590/S0102-695X2007000100003.
  •  
  1. Rolim Neto P, Lyra M, Silva R, Nunes L, Alves M, Rolim L, et al. Effervescent pharmaceutical composition and use of ethanolic extract of Bauhinia forficat. BR 10 2013 024150 4 A2. 2015. Available from: https://repositorio.ufpe.br/handle/123456789/35645.
  2. Verônica Cardoso de Souza B, de Morais Sousa M, Augusto Gasparotto Sattler J, Cristina Sousa Gramoza Vilarinho Santana A, Bruno Fonseca de Carvalho R, de Sousa Lima Neto J, et al. Nanoencapsulation and bioaccessibility of polyphenols of aqueous extracts from Bauhinia forficata link. Food Chem (Oxf). 2022;5:100144. Available from: https://doi.org/10.1016%2Fj.fochms.2022.100144.
  3. Swain T, Hills WE. The phenolic constituents of Prunus domestica. I- quantitative analysis of phenolics constituents. J Sci Food Agric. 1959;19:63-68. Available from: https://ui.adsabs.harvard.edu/link_gateway/1959JSFA...10...63S/doi:10.1002/jsfa.2740100110
  4. Zhishen J, Mengcheng T, Jianming W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 1999;64:555-559. Available from: https://doi.org/10.1016/S0308-8146(98)00102-2.
  5. Kim DO, Lee KW, Lee HJ, Lee CY. Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J Agric Food Chem. 2002 Jun 19;50(13):3713-7. Available from: https://doi.org/10.1021/jf020071c.
  6. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999 May;26(9-10):1231-7. Available from: https://doi.org/10.1016/s0891-5849(98)00315-3.
  7. Arnous A, Makris DP, Kefalas P. Correlation of pigment and flavanol content with antioxidant properties in selected aged regional wines from Greece. J Food Compos Anal. 2002;15:655-665. Available from: https://doi.org/10.1006/jfca.2002.1070.
  8. Prior RL, Hoang H, Gu L, Wu X, Bacchiocca M, Howard L, et al. Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples. J Agric Food Chem. 2003 May 21;51(11):3273-9. Available from: https://doi.org/10.1021/jf0262256.
  9. Dávalos A, Gómez-Cordovés C, Bartolomé B. Extending applicability of the oxygen radical absorbance capacity (ORAC-fluorescein) assay. J Agric Food Chem. 2004 Jan 14;52(1):48-54. Available from: https://doi.org/10.1021/jf0305231.
  10. Cuyckens F, Claeys M. Mass spectrometry in the structural analysis of flavonoids. J Mass Spectrom. 2004 Jan;39(1):1-15. Available from: https://doi.org/10.1002/jms.585.
  11. Farag MA, Sakna ST, El-Fiky NM, Shabana MM, Wessjohann LA. Phytochemical, antioxidant and antidiabetic evaluation of eight Bauhinia L. species from Egypt using UHPLC-PDA-qTOF-MS and chemometrics. Phytochemistry. 2015 Nov;119:41-50. Available from: https://doi.org/10.1016/j.phytochem.2015.09.004. 
  12. Ferreres F, Gil-Izquierdo A, Vinholes J, Silva ST, Valentão P, Andrade PB, et al. Bauhinia forficata Link authenticity using flavonoids profile: relation with their biological properties. Food Chem. 2012 Sep 15;134(2):894-904. Available from: https://doi.org/10.1016/j.foodchem.2012.02.201.
  13. Diderich R. The OECD chemicals program. In: Risk Assessment of Chemicals. Dordrecht: Springer. 2007; 623-638. Available from: http://dx.doi.org/10.1007/978-1-4020-6102-8_16.
  14. Malone MH. The pharmacological evaluation of natural products--general and specific approaches to screening ethnopharmaceuticals. J Ethnopharmacol. 1983 Aug;8(2):127-47. Available from: https://doi.org/10.1016/0378-8741(83)90050-8.
  15. Cunha LC, Azeredo FS, Mendonça AC, Vieira MS, Pucci LL, Valadares MC, et al. Assessment of acute and subacute toxicity, in rats, of the ethanolic extract of the leaves and latex of Synadenium umbellatum Pax. Rev Bras Farmacogn. 2009;19(2):403-411. Available from: https://doi.org/10.1590/S0102-695X2009000300012.
  16. Brito AS. Manual de ensaios toxicológicos in vivo. Campinas: UNICAMP; 1994. 122 p. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/lil-641100.
  17. da Silva AP, Oliveira GL, Medeiros SC, Sousa AM, Lopes Lda S, David JM, et al. Pre-clinical toxicology of garcinielliptone FC, a tautomeric pair of polyprenylated benzophenone, isolated from Platonia insignis Mart seeds. Phytomedicine. 2016 May 15;23(5):477-82. Available from: https://doi.org/10.1016/j.phymed.2016.02.013.
  18. Speit G, Rothfuss A. The comet assay: a sensitive genotoxicity test for the detection of DNA damage and repair. Methods Mol Biol. 2012;920:79-90. Available from: https://doi.org/10.1007/978-1-61779-998-3_6
  19. Ferreira FAG, Silva FC, Carvalho CM, Costa JC, Ferreira JMR. Hematological and plasma biochemical profile of mice after ingestion of the Arrabidaea chica plant. Scientia Plena. 2016;12(9). Available from: https://doi.org/10.14808/sci.plena.2016.091005.
  •  
  1. Fröde TS, Medeiros YS. Animal models to test drugs with potential antidiabetic activity. J Ethnopharmacol. 2008 Jan 17;115(2):173-183. Available from: https://doi.org/10.1016/j.jep.2007.10.038.
  2. Matteucci E, Giampietro O. Proposal open for discussion: defining agreed diagnostic procedures in experimental diabetes research. J Ethnopharmacol. 2008 Jan 17;115(2):163-172. Available from: https://doi.org/10.1016/j.jep.2007.08.040.
  3. Pereira ACS, Ribeiro GE, Souza LCR, Rufino LRA, Cabral ISR, Boriollo MFG, et al. Biologic activity of the hydroalcoholic extract of Bauhinia forficata Link on Herpetomonas samuelpessoai (Galvão.) Roitman. Rev Bras Plantas Med. 2014;16(3):585-592. Available from: https://doi.org/10.1590/1983-084X/13_093.
  4. Pan Y, Wang C, Chen Z, Li W, Yuan G, Chen H. Physicochemical properties and antidiabetic effects of a polysaccharide from corn silk in high-fat diet and streptozotocin-induced diabetic mice. Carbohydr Polym. 2017 May 15;164:370-378. Available from: https://doi.org/10.1016/j.carbpol.2017.01.092.
  5. Ribeiro AFC, Telles TC, Ferraz VP, Souza-Fagundes EM, Cassali GD, Carvalho AT, et al. Effect of Arrabidaea chica extracts on the Ehrlich solid tumor development. Rev Bras Farmacogn. 2012;22(2):364-373. Available from: https://doi.org/10.1590/S0102-695X2011005000225.
  6. Li PB, Lin WL, Wang YG, Peng W, Cai XY, Su WW. Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats. Int J Biol Macromol. 2012 Dec;51(5):749-55. Available from: https://doi.org/10.1016/j.ijbiomac.2012.07.007.
  7. Wang C, Chen Z, Pan Y, Gao X, Chen H. Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice. Food Chem Toxicol. 2017 Oct;108(Pt B):498-509. Available from: https://doi.org/10.1016/j.fct.2017.01.007.
  8. Franco RR, da Silva Carvalho D, de Moura FBR, Justino AB, Silva HCG, Peixoto LG, et al. Antioxidant and anti-glycation capacities of some medicinal plants and their potential inhibitory against digestive enzymes related to type 2 diabetes mellitus. J Ethnopharmacol. 2018 Apr 6;215:140-146. Available from: https://doi.org/10.1016/j.jep.2017.12.032.
  9. Bjørklund G, Chirumbolo S. Role of oxidative stress and antioxidants in daily nutrition and human health. Nutrition. 2017 Jan;33:311-321. Available from: https://doi.org/10.1016/j.nut.2016.07.018.
  10. Saliu JA, Ademiluyi AO, Akinyemi AJ, Oboh G. Propriedades antidiabetes e anti-hipertensoras in vitro de extratos fenólicos de folhas amargas (Vernonia amygdalina Del.). J Food Biochem. 2012;36(5):569-76.
  11. Da Silva KL, Filho VC. Plants of the genus Bauhinia: chemical composition and pharmacological potential Quím Nova. 2002;25(3):449-54. Available from: https://doi.org/10.1590/S0100-40422002000300018
  12. Filho VC. Chemical composition and biological potential of plants from the genus Bauhinia. Phytother Res. 2009;23(10):1347-54. Available from: https://doi.org/10.1002/ptr.2756
  13. Farias LS, Mendez AS. LC/ESI-MS method applied to characterization of flavonoids glycosides in B. forficata subsp. pruinosa. Quím Nova. 2014;37(3):483-6. Available from: https://doi.org/10.5935/0100-4042.20140069
  14. Santos M, Fortunato RH, Spotorno VG. Analysis of flavonoid glycosides with potential medicinal properties on Bauhinia uruguayensis and Bauhinia forficata subspecies pruinosa. Nat Prod Res. 2018;33:1-5. Available from: http://dx.doi.org/10.1080/14786419.2018.1460826
  15. Düsman E, Almeida IVD, Coelho AC, Balbi TJ, Düsman Tonin LT, Vicentini VEP. Antimutagenic effect of medicinal plants Achillea millefolium and Bauhinia forficata in vivo. Evid Based Complement Alternat Med. 2013;2013:893050. Available from: https://doi.org/10.1155/2013/893050
  16. Pepato MT, Baviera AM, Vendramini RC, Brunetti IL. Evaluation of toxicity after one-months treatment with Bauhinia forficata decoction in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2004;4(1):7. Available from: https://doi.org/10.1186/1472-6882-4-7
  17. Teo S, Stirling D, Thomas S, Hoberman A, Kiorpes A, Khetani VA. A 90-day oral gavage toxicity study of p-methylphenidate and d,l-methylphenidate in Sprague Dawley rats. Toxicology. 2002;179:183-196. Available from: https://doi.org/10.1016/s0300-483x(02)00338-4
  18. Lu L, Fan Y, Yao W, Xie W, Guo J, Yan Y, et al. Safety assessment of the fermented Phylloporia ribis (Lonicera japônica Thunb.) mycelia by oral acute toxicity study in mice and 90-day feeding study in rats. Food Chem Toxicol. 2014;69:18-24. Available from: https://doi.org/10.1016/j.fct.2014.03.044
  19. De Sousa Lino C, Diógenes JPL, Pereira BA, Faria RAPG, Neto MA, Alves RS, Viana GSB. Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats. Biol Pharm Bull. 2004;27(1):125-127. Available from: https://doi.org/10.1248/bpb.27.125
  20. Varela-Barca F, Agnez-Lima LF, De Medeiros SRB. Base excision repair pathway is involved in the repair of lesions generated by flavonoid-enriched fractions of pepper tree (Schinus terebinthifolius, Raddi) stem bark. Environ Mol Mutagen. 2007;48(8):672-681. Available from: https://doi.org/10.1002/em.20334
  21. Hodek P, Trefil P, Stiborová M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact. 2002;139(1):1-21. Available from: https://doi.org/10.1016/s0009-2797(01)00285-x
  22. Skibola CF, Smith MT. Potential health impacts of excessive flavonoid intake. Free Radic Biol Med. 2000;29(3-4):375-383. Available from: https://doi.org/10.1016/s0891-5849(00)00304-x
  23. Okonkwo COJ, Ehileboh AD, Nwobodo E, Dike CC. The effects of acute gasoline vapor inhalation on some hematological indices of albino Wistar rats. J Acute Dis. 2016;5(2):123-125. Available from: http://dx.doi.org/10.1016/j.joad.2015.11.005
  24. Cerqueira FM, De Medeiros MHG, Augusto O. Dietary antioxidants: controversies and perspectives. Quím Nova. 2007;30(2):441. Available from: https://doi.org/10.1590/S0100-40422007000200036
  25. Martínezmartínez BB, Pereira ACC, Muzetti JH, De Paiva Telles F, Mundim FGL, Teixeira MA. Bauhinia forficata and glucocorticoid-induced insulin resistance. Int J Sci Res. 2018;6(10).
  26. Cobble ME, Peters AL. Clinical practice in type 2 diabetes: After metformin and lifestyle, then what? J Fam Pract. 2009;58(11 Suppl Clinical): S7-14. Available from: https://pubmed.ncbi.nlm.nih.gov/19891948/
  27. Ahmed AS, Elgorashi EE, Moodley N, Mcgaw LJ, Naidoo V, Eloff JN. The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhea. J Ethnopharmacol. 2012;143(3):826-839. Available from: https://doi.org/10.1016/j.jep.2012.08.004
  28. Cazarolli LH, Folador P, Moresco HH, Brighente IMC, Pizzolatti MG, Silva FRMB. Mechanism of action of the stimulatory effect of apigenin-6-C-(2 ″-O-α-l-rhamnopyranosyl)-β-l-fucopyranoside on 14C-glucose uptake. Chem Biol Interact. 2009;179(2-3):407-412. Available from: https://doi.org/10.1016/j.cbi.2008.11.012
  29. Cazarolli LH, Pereira DF, Kappel VD, Folador P, Figueiredo MDSRB, Pizzolatti MG, et al. Insulin signaling: a potential signaling pathway for the stimulatory effect of kaempferitrin on glucose uptake in skeletal muscle. Eur J Pharmacol. 2013;712(1-3):1-7. Available from: https://doi.org/10.1016/j.ejphar.2013.02.029
  30. Ren J, Lu Y, Qian Y, Chen B, Wu T, Ji G. Recent progress regarding kaempferol for the treatment of various diseases. Exp Ther Med. 2019;18(4):2759-76. Available from: https://doi.org/10.3892/etm.2019.7886
  31. Sharma B, Balomajumder C, Roy P. Hypoglycemic and hypolipidemic effects of flavonoid-rich extract from Eugenia jambolana seeds on streptozotocin-induced diabetic rats. Food Chem Toxicol. 2008;46(7):2376-2383. Available from: https://doi.org/10.1016/j.fct.2008.03.020
  32. Grygiel-Górniak B. Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications-a review. Nutr J. 2014;13:17. Available from: https://doi.org/10.1186/1475-2891-13-17
  33. Mirza AZ, Althagafi II, Shamshad H. Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications. Eur J Med Chem. 2019;166:502-513. Available from: https://doi.org/10.1016/j.ejmech.2019.01.067
  34. Tonelli CA, de Oliveira SQ, da Silva Vieira AA, Biavatti MW, Ritter C, Reginatto FH, et al. Clinical efficacy of capsules containing standardized extract of Bauhinia forficata Link (pata-de-vaca) as adjuvant treatment in type 2 diabetes patients: A randomized, double-blind clinical trial. J Ethnopharmacol. 2022;282:114616. Available from: https://doi.org/10.1016/j.jep.2021.114616
  35. Xu H, Luo J, Huang J, Wen Q. Flavonoids intake and risk of type 2 diabetes mellitus: A meta-analysis of prospective cohort studies. Medicine. 2018;97(19):e0686. Available from: https://doi.org/10.1097/md.0000000000010686
  36. Volpato GT, Damasceno DC, Rudge MVC, Padovani CR, Calderon IDMP. Effect of Bauhinia forficata aqueous extract on the maternal-fetal outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats. J Ethnopharmacol. 2008;116(1):131-137. Available from: https://doi.org/10.1016/j.jep.2007.11.013
  37. Damasceno DC, Volpato GT, Calderon IDMP, Aguilar R, Rudge MC. Effect of Bauhinia forficata extract in diabetic pregnant rats: maternal repercussions. Phytomedicine. 2004;11(2/3):196-201. Available from: https://doi.org/10.1078/0944-7113-00348
  38. Pepato MT, Conceição CQ, Gutierres VO, Vendramini RC, Souza CRF, Oliveira WP, Brunetti IL. Evaluation of the spouted bed dried leaf extract of Bauhinia forficata for the treatment of experimental diabetes in rats. Afr J Biotechnol. 2010;9(42):7157-64. Available from: http://hdl.handle.net/11449/226097.
  39. Pepato MT, Keller EH, Baviera AM, Kettelhut IC, Vendramini RC, Brunetti IL. Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats. J Ethnopharmacol. 2002;81(2):191-197. Available from: https://doi.org/10.1016/s0378-8741(02)00075-2
  40. Mollica A, Zengin G, Locatelli M, Stefanucci A, Macedonio G, Bellagamba G, et al. An assessment of the nutraceutical potential of Juglans regia L. leaf powder in diabetic rats. Food Chem Toxicol. 2017;107:554-564. Available from: https://doi.org/10.1016/j.fct.2017.03.056
  41. Bakhti M, Böttcher A, Lickert H. Modelling the endocrine pancreas in health and disease. Nat Rev Endocrinol. 2019 Mar;15(3):155-171. Available from: https://doi.org/10.1038/s41574-018-0132-z
  42. Defronzo RA, Ferrannini E, Groop L, Henrique RR, Herman WH, Holst JJ, et al. Type 2 diabetes mellitus. Nat Rev Dis Primers. 2015;1:15019. Available from: https://doi.org/10.1038/nrdp.2015.19
  43. Chen L, Gnanaraj C, Arulselvan P, El-Seedi H, Teng H. A review on advanced nanoencapsulation technology to enhance bioavailability of phenolic compounds: based on its activity in the treatment of type 2 diabetes. Trends Food Sci Technol. 2019;85:149-162. Available from: https://doi.org/10.1016/j.tifs.2018.11.026
  44. Alves EP, Freires IA, Rosalen PL, Ruiz AL, Granville-Garcia AF, Godoy GP, et al. Antimicrobial and antiproliferative activity of Bauhinia forficata Link and Cnidoscolus quercifolius extracts commonly used in folk medicine. J Contemp Dent Pract. 2017;18(8):635-640. Available from: https://doi.org/10.5005/jp-journals-10024-2098

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