Aim of this work is to analyze the coronavirus viral surface properties related the pattern of electrical features.
This chemical physical property is relevant and crucial to set profile of diffusion, severity of disease, efficacy of therapeutic strategy and in order to search new way to fight COVID-19 and the NEW VARIANT.
The phenomena of immune evasion and the different pattern of efficacy towards variants of some vaccine or some antibodies combination produce the need to verify if considering the electrical feature of viral surface can be a right tool or not.
As result of this research it is possible to submit to the scientist that the viral surface properties and electrical feature can be an element to be considered in various preventive or treatment measure.
The specificity of action of some vaccine or antibodies seem to tell us that also the aspecific methods are useful.
A specific chemico physical factors can influence the electrical charges viral surface behavior.
Hpertonic saline solution, humidity, electrical charge barrier in mask are simply example of the effect.
That can be obtained action on viral surface chemico -physical properties.
Related the physio-pathological process of COVID-19 disease it is interesting to focus to the aspect.
Played by interaction of Sars-Cov-2 protein with integrins of human epithelial pulmonary cell.
A bio molecular approach help in to deeply verify the involved factors and the results of this Activation RGD mediated.
Of Great interest also the relationship with some vaccine strategy followed by the various pharmaceutical industry.
The results of this work will be useful to think modification in some vaccine increasing the global safety and related some rare ADR.
Related the need to search new strategy in vaccine design in order to reduce also some rare effect like trombosys for some registered products it is interesting the role played by the SPIKE RGD domain.
The binding with molecules like Fibronectin is a process that must to be deeply investigated.
A better understanding in this process can be used to improve safety of the new generation of COVID vaccine.
The rare effect like thrombosis recognized by regulatory agency produced a modification of technical data sheet of some vaccine so the phenomena Is interesting to be more investigated.
Spike protein and its domains are involved in producing pathological effect of the COVID-19 disease.
What it is interesting is that some pathological effect of this pathology are similar to some rare side effect produced by some COVID-19 vaccine classes.
After a review of interesting literature related this topics is submitted an experimental projects able to verify in vitro the spike procoaugulant property.
Before actual COVID-19 pandemia coronavirus was not so dangerous like now.
In December 2019 - January 2020 in Wuhan first and then in other places this coronavirus was responsible of a first wave of severe pulmonitis responsible of many deaths.
Wuhan and other region involved first was high level air polluted and industrial area.
New COVID-19 variant in last part of 2020 and in first month of 2021 was responsible of great diffusion of this pandemic disease.
UK, South Africa and brasilian new variant show higher diffusion then the first wave of COVID-19.
Aim of this work is to analyze relationship with air pollution and the possibility that mutagen substantia inside of this microenvironment can produce new variant trough an genetic pressure process.
RNA viruses are normally subjected by natural mutation but some phenomena can contribute to accelerate this process and their airborne – aeresols microenvironment is relevant.
Some air pollutants are recognized as mutagen factors by literature.
Related COVID-19 and new Variant and treatment like vaccine it is relevant to deeply verify the immunologic implication and in a special way regarding the innate immune sensor system and the evasion of the immune system.
This can be crucial to search for new strategies to fight this severe disease under a Toxicology-antidotes point of view.
The rapid emergence of a new variant is under study by researchers because some of these show different responses to antibodies as reported in literature (vaccine efficacy?).
In this article after a review part it is submitted a collection of hypothesis of solution to contrast COVID-19.
Spread and mortality and project hypothesis.
A new toxicological approach also in a viral respiratory disease can be a novelty to adequately fight this severe condition and this focusing not only towards specific immunity but also a specific measures.
A toxicological approach in drug- vaccine like products designing makes it possible to get the clinical outcomes needed.
Related COVID vaccine production many different strategies was followed by the producers.
Observing some rare event of thrombosis after some COVID-19 vaccination, it is interesting to verify if the Target used for the manufacturing can be involved in a different procoagulant activity or not.
Some vaccine are suspended in some country or under a deep new verify- investigation by the regulatory agency. (EU or USA).
This fact it is relevant.
The target SPIKE-PROTEIN FULL LENGTH modified or not or towards the RBD domain can be a relevant factor.
Mauro Luisetto*, Naseer Almukhtar, Ahmed Yesvi Rafa, Behzad Nili Ahmadabadi, Ghulam Rasool Mashori, Farhan Ahmad Khan, Ram Kumar Sahu, Gamal Abdul Hamid and Khaled Edbey
Aim of this work is to verify the effect of some neurotoxins, physical factors and geography in presentation of some Relevant Neurological disorder like some form of ASL, PD, AD.
The geographic diffusion of the ASL/PD in west pacific (GUAM foci), and mutation of SOD 1 and other mutations are interesting facts to verify the recent literature about the neurotoxic process.
Related to the references presented a global conclusion about the pathogenetic progression of some neurological disease will be produced as instrument for new hypothesis and for the introduction of new innovative therapeutic strategies.
Luisetto M*, Naseer Almukthar, Edbey K, Tarro G, Nili B Ahmadabadi, Cabianca L, Mashori Gulam Rasool, Gadama G Prince and Oleg Yurevich Latyshev
Published on: 13th October, 2022
The aim of this work is to report some interesting references and documents related to the mRNA vaccine. Every cited reference can act as an instrument to better understand what some independent researchers find: this work is mainly focused on the public debate related presence/absence of graphene derivates in some vaccine vials for COVID-19. Relevant classic articles White Papers or other kinds of a document are useful instruments to better clarify some crucial aspects of this infectious disease, its epidemiology and the efficacy of the measure adopted (preventive, therapeutic, or vaccine).If the reviewed article show an intrinsic recognized international value other kinds of source like a White Paper or other documents can be of interest to generate hypotheses or to open public discussion on crucial topics. For this reason, it is useful to use this method also in the discussion related to impurity profiles in new innovative bio-pharmaceuticals like the mRNA vaccine. The fact that this product was introduced with an emergency authorization, whit reduced the time of experimentation and due to the lack of official quality information related to some raw materials used authorizes us to use also this method.Even if the international official regulatory agency does not find this substance in the control for release of the lots it is interesting to more deeply investigate what funded by an independent researcher in some vials of vaccine or sample patient’s blood after vaccination. This reference even if not a smoking gun the same can stimulate the reasoning about the general concept involved. It is needed, to read this work, to consider the intrinsic limitation of some of the study research reported (White Paper) or the other documents.
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